STUDIES ON DIRECT COOMBS REACTION BY CEFAZOLIN IN VITRO

In vitro studies with cefazolin.

Susceptibilities of 259 isolates of pathogenic bacteria to cefazolin were measured by broth and agar dilution procedures. Beta-hemolytic streptococci were inhibited by 0.25 mug/ml, whereas Staphylococcus aureus and alphahemolytic streptococci were inhibited by 2.0 mug/ml. Enterococci were resistant to less than 32 mug/ml. Wide variation was seen with gram-negative species. Most isolates of Kleb...

The effect of antisperm antibodies measured by direct mixed agglutination reaction on in vitro fertilization rate

Background: Although in vitro fertilization (IVF) has been found to bypass the inhibitory effect of high levels of antisperm antibodies on sperm motility, fertilization rates are reduced in approximately 40% of the attempts. In this study, we investigated the relationship between antisperm antibodies measured by the direct mixed agglutination reaction (MAR) and the fertilization rate in inferti...

Positive direct Coombs test induced by phenylhydrazine.

Anemia with positive direct Coombs' test induced by trypan blue.

as evidence of autoimmune phenomena. The experimental production of positive antiglobulin tests by drugs and chemical agents, however, has suggested that nonimmunologic mechanisms may also be responsible for protein coating of erythrocytes.2’3 During attempts to produce tumors of the reticuloendothelial system in rats by injection of trypan blue, an anemia, chacacterized by increased ervthrocyt...

SERUM SICKNESS-LIKE REACTION ASSOCIATED WITH CEFAZOLIN: CASE REPORT By

Background: Although rare, serum sickness-like reactions have been documented to occur following the administration of many antibiotics including the second generation cephalosporin cefaclor. Cefazolin, which belongs to the first generation of the same drug class, is a commonly prescribed antibiotic which is considered to be generally safe and well tolerated. There have been no prior reports li...